Hypospadias and Genital Development

Zusatztext

. 31 G. HyunandT. Kolon EndocrineAbnormalitiesinBoyswithHypospadias. 45 R. I. Silver GeneticandClinicalStudiesonHypospadias. ---. --. -. 73 A. Nordenskjold SECTIONII. MECHANISMOFGENITALDEVELOPMENT DevelopmentofthePenileUrethra. 87 G. CunhaandL. Baskin AnatomicalStudiesoftheMouseGenitalTubercle. 103 L. Baskin,W. Liu,J. Bastacky,andS. Yucel AnatomicalStudiesoftheFibroblastGrowthFactor-l0Mutant,Sonic HedgeHogMutant,andAndrogenReceptorMutantMouseGenital Tubercle. -. --. 123 S. Yllcel,W. Liu,DCordero,A. Donjacour,G. Cunha,andL. Baskin DevelopmentalGeneticsofHypospadias. 149 M. Cohn xiii xiv Contents DevelopmentoftheMouseExternalGenitalia: UniqueModelof Organogenesis. 159 K. Suzuki, K. Shiota,Y. Zhang,L. Lei,andG. Yamada NewConceptsontheDevelopmentoCtheVagina. 173 E. Shapiro. H. Huang,andX. R. Wu SECTIONIII. ENDOCRINEDISRUPTORSANDSEXUAL DIMORPHISMINTHEANIMALKINGDOM EndocrineDisruptionOverview: AreMalesatRisk? 189 T. Colburn EndocrineDisruptionandHypospadias. 203 G. Steinhardt Toxicant-InducedHypospadiasintheMaleRat · 217 L. E. Gray. I. Ostby,J. Fun,C. Wolf,C. Lambright,V. Wilson, and N. Noreiga MasculinizationofFemaleMammals: LessonsfromNature. 243 N. J. PI:H'candS. Glickman Index. 255 SectionI Introduction HYPOSPADIAS LaurenceS. Baskin* M. D. ,FAAP 1.

Autorenportrait

InhaltsangabeSection I. Human Studies.- Epidemiology of Hypospadias.- Endocrine Evaluation of Hypospadias.- Endocrine Abnormalities in Boys with Hypospadias.- Genetic and Clinical Studies on Hypospadias.- Section II. Mechanism of Genital Development.- Development of the Penile Urethra.- Anatomical Studies of the Mouse Genital Tubercle.- Anatomical Studies of the Fibroblast Growth Factor-10 Mutant, Sonic Hedge Hog Mutant, and Androgen Receptor Mutant Mouse Genital Tubercle.- Developmental Genetics of Hypospadias.- Development of the Mouse External Genitalia: Unique Model of Organogenesis.- New Concepts on the Development of the Vagina.- Section III. Endocrine Disruptors and Sexual Dimorphism in the Animal Kingdom.- Endocrine Disruption Overview: Are Males at Risk?.- Endocrine Disruption and Hypospadias.- Toxicant-Induced Hypospadias in the Male Rat.- Masculinization of Female Mammals: Lessons from Nature.

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