Peroxisome Proliferator-Activated Receptors

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<p>All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In<i>Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances</i>, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described.</p><p></p>As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways,<i> Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances</i> aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.

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